### Evaluation and Management of Chronic Obstructive Pulmonary Disease (COPD): A Case Study Approach

#### Pathophysiology & Clinical Findings of the Disease

1. **Are the spirometry results consistent with obstructive or restrictive pulmonary disease? What is the most likely pulmonary diagnosis for this patient?**
– The spirometry results show a reduced FEV1/FVC ratio (56% pre-bronchodilator, 52% post-bronchodilator) and an FEV1 of 64% predicted, which is characteristic of obstructive pulmonary disease. The most likely diagnosis is Chronic Obstructive Pulmonary Disease (COPD).

2. **Explain the pathophysiology associated with the chosen pulmonary disease.**
– COPD is characterized by chronic inflammation leading to structural changes and narrowing of the small airways. It involves the destruction of lung parenchyma, loss of alveolar attachments, and decreased elastic recoil, which result in airflow limitation and impaired gas exchange. Chronic exposure to irritants, primarily tobacco smoke, leads to an inflammatory response in the lungs, further exacerbating the condition.

3. **Identify at least three subjective findings from the case which support the chosen diagnosis.**
– Fatigue.
– Dyspnea with exertion.
– Dry, nonproductive cough in the morning.

4. **Identify at least three objective findings from the case which support the chosen diagnosis.**
– Wheezing noted with forced exhalation.
– Prolonged expiratory phase on auscultation.
– Hyper-inflated lungs with a flattened diaphragm on chest X-ray.

#### Management of the Disease

*Utilize the required Clinical Practice Guideline (CPG) to support your treatment recommendations.*

1. **Classify the patient’s disease severity. Is this considered stable or unstable?**
– Based on the GOLD criteria, the patient’s COPD severity is classified as GOLD 2 (Moderate) due to an FEV1 of 64% predicted. Given the lack of improvement in symptoms and worsening breathlessness, this condition is considered unstable.

2. **Identify two (2) “Evidence A” recommended medication classes for the treatment of this condition and provide an example (drug name) for each.**
– Long-acting beta2-agonists (LABAs): Salmeterol.
– Inhaled corticosteroids (ICS): Fluticasone.

3. **Describe the mechanism of action for each of the medication classes identified above.**
– **LABAs (Salmeterol):** These medications stimulate beta2-adrenergic receptors in the airway smooth muscle, leading to bronchodilation and improved airflow.
– **ICS (Fluticasone):** These drugs reduce inflammation in the airways by inhibiting multiple inflammatory cytokines, leading to decreased airway hyperresponsiveness and reduced symptoms.

4. **Identify two (2) “Evidence A” recommended non-pharmacological treatment options for this patient.**
– Smoking cessation programs: Essential for halting the progression of COPD and improving overall lung function.
– Pulmonary rehabilitation: A comprehensive intervention including exercise training, education, and behavior change to improve physical and psychological condition.

#### References

(Here, you would list your references in APA format on a separate page.)

### References

– Global Initiative for Chronic Obstructive Lung Disease. (2024). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. https://goldcopd.org/
– Author, A. A. (Year). Title of the textbook. Publisher.
– Author, B. B. (Year). Title of the journal article. *Journal Name*, *Volume*(Issue), pages. DOI

(Note: Replace placeholder text with actual references as per APA guidelines.)

 

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